Review Meeting

Developing a successful HIV/AIDS research program in the current competitive funding climate is challenging and may be greatly enhanced by the generation of supportive preliminary data, networking with faculty members that have complimentary research experience, and support from an established mentor. The CFAR Developmental Core provides resources and services to CFAR members to enhance career development in basic, clinical or social and behavioral sciences. Resources and services provided by the Developmental Core include funding for small grants to assist CFAR members in the generation of preliminary data to support grant proposals submitted to external funding agencies. The Developmental Core also participates in recruitment of faculty with HIV/AIDS research expertise not currently represented at Duke to enhance the HIV/AIDS research network. Finally, the Developmental Core provides mentoring resources and services, and it works to partner junior CFAR members with established CFAR members to serve as mentors able to provide guidance and support to enhance faculty development. 

Services Offered

Research Support is offered through several funding mechanisms.

Microgrant Awards
Pilot Awards
Administrative Supplement Awards

Name Title Award Year
Dana Pasquale Investigation of HIV Cluster Concordance across Genomic Regions Microgrant 2024
Sho Sugawara Recharging NK cell cytotoxicity and trafficking for HIV-1/SIV cure Microgrant 2024
Liping Feng Pregnant with cART and PFAS: the maternal and fetal cardiovascular outcomes Microgrant 2024
Jennie Dougherty Informing Shared Decision-Making Practices for HIV Exposed Infant Feeding at Duke University Microgrant 2024
Julian Hertz Cardiovascular Risk Among Tanzanian Adults with HIV (Standard) Pilot Award 2024
Jackie Hodges Integrating PrEP into mobile addiction and primary care services (Standard) Pilot Award 2024
Asiya Gusa Developing a reporter system to study stress-activation of retroelements during HIV/Cryptococcus co-infection of macrophages (Focused) Pilot Award 2024
Philippe Rascle Multi-omic analysis of MHC-E-dependent SIV-specific memory NK cells in SIV infected rhesus macaques to develop new HIV cure strategy (Focused) Pilot Award 2024
Naseem Alavian HIV care engagement: Identifying predictors of engagement and building a colaboration with the Durham County Health Department Pilot Award 2023
Suur Ayangeakaa A community-informed strategy for understanding and addressing the influence of HI-related and intersectional stigmas on access to and uptake (use) of pre-exposure prophylaxis (PrEP) among cisgender African American women Pilot Award 2023
Emily Niehaus Clinic-based incentives to promote patient uptake of long-acting injectable antiretroviral therapy for the treatment of HIV Pilot Award 2023
Daniel Schuster Leveraging single B cell clonal lineage tracing to unravel the fine-tuning of antiviral Fc effector functions Pilot Award 2023
Charles Burns Expanding the reach of an HIV rapid response re-engagement team (H3RT): assessing the readiness of key stakeholders and identifying predictors of re-engagement. Pilot Award 2022
Cordelia Manickam Role of eosinophils in lentiviral infection Pilot Award 2022
Elliott SoRelle Resolving spatially heterogeneous expression in EBV+ Non-Hodgkin Lymphomas from HIV+ individuals and their correlation to tractable in vitro disease models Pilot Award 2022
Lynn Lin Develop a context-sensitive statistical framework for analyzing flow cytometry and other summary data to identify Immune correlates of protection Pilot Award 2022
Schenita Randolph Examining Organizational Culture and Context of Beauty Salons for Scalability and Sustainability of a Salon-Based Intervention to Improve the Awareness, Knowledge and Uptake of PrEP among Black Women in the United States South Microgrant 2022
Sandeep Dave Defining the tumor microenvironment of HIV+ diffuse large B cell lymphoma Pilot Award 2021
Tiarney Ritchwood Characterizing treatment regimen fatigue among older adults living with HIV Pilot Award 2021
Stella Berendam Enhancing anti-HIV-1 broadly neutralizing antibody IgG1 mucosal distribution via fusion to polymeric Ig receptor binding peptide Pilot Award 2021
Marina Tuyishime Characterization of Kaposi’s Sarcoma-specific ADCC responses and NK cell populations in HIV-infected individuals Pilot Award 2021
Neil Surana Determining the role of the gut microbiota in HIV acquisition Pilot Award 2021
Brandon Knettel Implementation Strategies for Integrating Treatment for Opioid Use Disorder in HIV Care Microgrant 2021
Howard Lee Metabolomic Profile In Risk Prediction Of Fibrosis Among People With HBV And HIV Coinfection Pilot Award 2020
Shanti Narayayansama Tackling a neglected HIV-associated infection - A validation study of the IgG and IgM serological responses to talaromycosis Pilot Award 2020
Charles Burns Advancing PrEP Delivery: An Assessment of the Readiness of Key Stakeholders for the Delivery of PrEP in the Urgent Care Setting Microgrant 2020
Mehri McKellar Engaging pharmacies for HIV prevention in South Carolina Special Project Award 2020
Amy Corneli HIV Prevention within the COVID-19 Context: HIV Risk and PrEP use Among Black Cisgender Women and Same Gender Loving Black Men in the U.S. South Special Project Award 2020
Michael Relf Testing the acceptability of an internalized stigma reduction intervention among women living with HIV (WLWH) in Rwanda Pilot Award 2019
Amelia Thompson Adolescent HIV-1 vaccine clinical trial acceptability and feasibility in North Carolina Pilot Award 2019
Melissa Watt HIV stigma reduction with men in Tanzania: Pilot test of a video and counseling intervention to reduce stigmatizing attitudes and promote linkage to HIV care Pilot Award 2019
Julian Hertz Myocardial infarction among persons living with HIV in northern Tanzania Pilot Award 2019
Xiaoying Shen Enhance subdominant B cell response against HIV envelope variable region 2 (V2) by overcoming competition from the immunodominant V3 region Pilot Award 2019
Kevin Tsai Regulation of HIV-1 replication by epitranscriptomic acetylation of cytidine in viral RNA transcripts Pilot Award 2019
Sweta Patel The impact of HIV infection or exposure on the upper respiratory microbiome of children in Botswana Pilot Award 2019
Laura Barisoni Spatial association between SHIV infection and structural changes in kidney of SHIV-infected Rhesus Macaques Microgrant 2019
Lance Okeke An EHR-based model to identify potential candidates for HIV pre-exposure prophylaxis in a Southern healthcare system Microgrant 2019
Dieter Mielke Novel lentiviral transduction system to study acutely- and latently-HIV-1 infected primary cells Microgrant 2019
Charles Muiruri Contextualizing factors associated with non-adherence to cardiovascular disease prevention strategies for people living with HIV who have achieved viral suppression Microgrant 2019
John Mitchell & Marie Stoner A community based approach to understanding PrEP care in at-risk adolescents Pilot Award 2018
Maria Blasi Optimization of IDLV mediated gene expression for therapeutic interventions against HIV-1 Microgrant 2018
Li Huang Activation and elimination of HIV-1 latently infected CD4 positive T cells Microgrant 2018
Nicholas Heaton Proof-of-concept studies to identify controllers of HIV-1 provirus transcription Microgrant 2018
Mari Shinohara Cellular and molecular mechanisms inducing cryptococcal immune reconstitution inflammatory syndrome (IRIS) Microgrant 2018
Julius Wilder Antiretroviral switches in HIV/HCV co-infected patients: Initiating direct acting antiviral therapies for Hepatitis C Infection Microgrant 2018
Gerald Bloomfield Evaluating Inflammatory Indicators of Cardiac Performance in Children with Perinatally Acquired Human Immunodeficiency Virus in Western Kenya Pilot Award 2017
Megan Huchko Coupling Cervical Cancer Screening with HIV Testing through Community Health Campaign in Western Kenya Pilot Award 2017
Genevieve Fouda & Joel Collier A Supramolecular, Self-Adjuvanting, Neonatal HIV Vaccine Pilot Award 2017
Matthew Kelly Investigating the role of the nasopharyngeal microbiome in mediating the increased susceptibility of HIV-exposed, uninfected infants to colonization and disease caused by Streptococcus pneumoniae Pilot Award 2016
Todd Bradley & Kevin Wiehe Mechanisms of VRC01-like antibody-virus co-evolution Pilot Award 2016
David Tobin & Stefan Oehlers Reversing vascular dysfunction as a novel therapy for mycobacterial infection Pilot Award 2016
Joy Noel Baumgartner Increasing HIV Testing and Counseling (HTC) via Adolescent Wellness Visits in Tanzania Pilot Award 2016
Kristin Schroeder Clinical and pathological pattern of peripheral lymphadenopathy in HIV-infected patients in Northern Tanzania Pilot Award 2015
Melissa Watt Identifying opportunities to promote engagement in HIV care following childbirth in South Africa. Pilot Award 2015
You-wen He Functional roles of the integration sites in HIV reservoir persistence Pilot Award 2015
Anna Maria Masci An HIV Ontology for Comprehensive and Reproducible GCLP Laboratory Pilot Award 2015
Loretta Que Effects of e-cigarettes on pulmonary inflammation and behavior in HIV+ smokers Pilot Award 2015
Maria Blasi In depth characterization of strong and long lasting antibody responses induced by a novel vaccination strategy Pilot Award 2014
Sheri Towe Impact of cognitive training on medication adherence in HIV-infected individuals Pilot Award 2014
Giny Fouda Mapping the fine specificity of maternal neutralizing antibodies that reduce the risk of perinatal HIV transmission Pilot Award 2014
Edward Kennedy Development of RNA-guided nucleases able to target and inactivate integrated HIV-1 proviruses in infected cells Pilot Award 2014
Weihong Lai Activation of Latent HIV-1 by Gnidimacrin Pilot Award 2014
Qi-Jing Li Lineage conversion of CD4+ T cells during T cell-mediated anti-HIV responses Pilot Award 2014
Joseph McClernon Novel Approaches to Reducing Tobacco-Related Harm among HIV-infected smokers. Pilot Award 2014
Micah Luftig AIDS Malignancy Support: defining the genetic and transcriptomic landscape of EBV in AIDS-associated lymphomas Pilot Award 2013
Susanna Naggie The role of a fetal morphogen in liver fibrosis progression in HIV/HCV coinfected
patients
Pilot Award 2013
Mehri McKellar Physical function and the role of metabolomics in HIV and aging Pilot Award 2013
Eve Puffer A model of family therapy for HIV prevention and adolescent emotional support in rural Kenya: A development and pilot study. Pilot Award 2013
Joern Coers Dissecting the role of pro-autophagic IRGM as a co-factor for HIV replication Pilot Award 2013
Lance Okeke Determinants of Myocardial Dysfunction in Persons Living with HIV Pilot Award 2013
Zhao Dang Small molecules targeting programmed death-1 for AIDS immunotherapy Pilot Award 2012
Dorothy Dow Establishing mental health needs in HIV positive adolescents in Tanzania Pilot Award 2012
Sallie Permar A novel HIV-neutralizing protein isolated from breast milk Pilot Award 2012
Xavier Preud'Homme Feasibility of nurse -administered insomnia therapy for improving adherence to HIV/AIDS treatment Pilot Award 2011
David Tobin Genetic susceptibility to tuberculosis in the context of HIV infection Pilot Award 2011
Jan Ostermann Feasibility of discrete choice
experiments to determine preferences for alternative HIV testing options in the Kilamanjaro region of
Tanzania
Pilot Award 2011
Sumedha Ariely Following children from institutions into communities; predictors of protective and adverse effects Pilot Award 2011
Giny Fouda Maternally -acquired and vaccine-induced functional HIV Env-specific antibody responses in HIV-exposed vaccinated infants Pilot Award 2011
Rebecca Skalsky Analysis of the miRNA targettome during EBV infection Pilot Award 2011
Christina Meade Prevalenceof HIV and Sex Risk Behavior in Methamphetamine Users in Cape Town Pilot Award 2011
Cliburn Chan Modeling T cell response to vaccination with replication -competent vectors in NHP Pilot Award 2011
Susanna Naggie Repository Pilot Award 2011
Susanna Naggie The role of antiretroviral-induced dyslipidemia in lipid-HCV interactions in HIV/HCV co-infected patients: an assessment of the effect on HCV viral replication Pilot Award 2011
Annie Buchanan Seroprevalence of Hepatitis B and C among HIV-Infected Children and Healthy Tanzanian Children in the Kilimanjaro Region Pilot Award 2010
Jeff Blackinton Effects of HIV Nef protein on the messenger RNAs encoding the immunological synapse Pilot Award 2010
David Pickup Improvement of MVA-HIV vaccines Pilot Award 2010
Thespina Yamanis Exploring Social Network Influences on Sexual Partnership Concurrency among Young Men in Tanzania Pilot Award 2010
Wenjun Li Genome organization & plasticity of Cryptococcus neoformans from AIDS Patients Pilot Award 2010
Ying-Lien Chen Role of calcineurin in virulence of Candida species that frequently infect patients with AIDS Pilot Award 2010
Ravi Jhaveri Hepatitis C virus pathogenesis and the hedgehog pathway Pilot Award 2010
Sara LeGrand Collaborative HIV Substance Use Treatment Development Project Pilot Award 2010
Min Ni Role of hyphal development in virulence of Cryptococcus neoformans Pilot Award 2010
Brianna Norton Prevalence, Severity and HIV Outcomes associated with Hepatitis B in a cohort of HIV positive Tanzanian Adults Pilot Award 2010
Giovanna Merli A comparison of two methodologies to sample female sex workers in Liuzhou, China Pilot Award 2009
Adam Wax Optical Coherence Tomography as a tool for evaluating the integrity of the vaginal epithelium Pilot Award 2009
Sally Kornbluth Harnessing caspases to eliminate cells latently infected with HIV-1 Pilot Award 2009
Timothy Haystead Validation of Host Proteins by HIV-1 infection for drug development Pilot Award 2009
Elizabeth Reddy Factors associated with virologic failure and suppression in Tanzanian children with HIV-1 infection receiving highly active antiretroviral therapy Pilot Award 2008
David Katz Is HIV Migration to Mucosal Surfaces Slowed by HIV-Aggregating Antibodies? Pilot Award 2008
Ana Litvintseva Gene Expression and Virulence of Crypytococcus neoforms Pilot Award 2008
John Brion Self-compassion and Adherence to Antiretroviral Therapy Pilot Award 2008
Jason Stout Geographic Information Systems-based Screening for TB, HIV and Syphilis Pilot Award 2008
Mehri McKellar HIV testing in the Duke University Medical Center Emergency Department Pilot Award 2008
Julie Adams Pilot of a measurement based care treatment for depression in an HIV clinic in Tanzania Pilot Award 2008
Susanna Naggie The effect of changes in lipid metabolism occurring upon initiation of ARV in HIV/HCV co-infected patients Pilot Award 2008
Eve Puffer Developing a multi-level prevention program in rural Kenya Pilot Award 2008
Wanda Lakey Ritonavir inhibition of peroxisomal 3,2-trans, enoyl CoA isomerase plays a role in lipid abnormalities in HIV Pilot Award 2008
Jan Osterman Enhancing VCT: Role of home-based couples counseling in VCT uptake and disclosure in rural Kilimanjaro Pilot Award 2008
Micah Luftig Mechanism of host innate tumor suppression in EBV-associated malignancy Pilot Award 2007
Ravi Jhaveri Role of domain 3 of HCV core protein in the development of steatosis Pilot Award 2007
Stefan Zauscher Understanding interactions of neutralizing antibodies with lipids and model lipid surfaces Pilot Award 2007
Mattia Bonsignori B cell fluorospot assay to detect distinct antibody secreting cells Pilot Award 2007
Guido Ferrari Correlation between HLA class 1 and alleles and in-vitro induced gene expression in lymphocytes of seronegative donors Pilot Award 2007
Shaunna Shen Studies of neutralizing antibodies targeting the 2F5 epitope of HIV Pilot Award 2007
David Murdoch The role of regulatory cells in the immune reconstitution inflammatory syndrome Pilot Award 2007
Mikhail Dobrikov Antiviral Borano NTP analogues for selective targeting of multi-drug resistant HIV Pilot Award 2007
Terry Oas  P Protein Project Pilot Award 2006
Li Huang Synthesis of bi-functional betulinic acid derivatives as potent anti-HIV agents Pilot Award 2006
David Katz Biophysical analysis of HIV transport and neutralization dynamics Pilot Award 2006
Laurent Verkoczy Generation and characterization 2F5 Hcki and 2F5 Hcki+LC transgenic mice Pilot Award 2006
Motonari Kondo Acceleration of T cell reconstitution by transplantation of bone marrow with ectopic CCR9 Pilot Award 2006
Kathryn Whetten Association of sociodemographic and psychosocial factors with anti-retroviral adherence and health outcomes in AIDS patients in North Tanzania Pilot Award 2006
Catherine Hoyo HIV infection in women infected with Human Papillomavirus (HPV) and those with squamous intraepithelial lesions in Tanzania Pilot Award 2006
Floyd Wormley Development of C. neoformans strains that express immune modulating cytokines for use in the treatment and prevention of cryptococcosis Pilot Award 2005
Gary Cox Clinical studies on Cryptococcosis in Tanzania Pilot Award 2005
John Crump Predictors of virologic failure and resistance among HIV-infected patients treated with fixed dose combination Stavudine/Lamivudine, Nevirapine in Northern Tanzania Pilot Award 2005
Investigator Title Year Awarded Funding Source
Lauren Brinkley-Rubinstein Evaluating the use of long-acting antiretroviral treatment for HIV during community re-entry: Addressing community and structural barriers 2023 Strategies to Improve Linkage to HIV Care and Services Post-Incarceration 
Charles Burns Leveraging Southern Community-Based Pharmacies for PrEP Referrals 2023 Leveraging Pharmacies to Advance HIV Testing, Prevention, and Care
Lance Okeke Evidence2Practice (E2P): Leveraging Implementation Science to Promote Careers in HIV Research among Historically Black College and University (HBCU) Students, Phase III 2023 CFAR Diversity, Equity, and Inclusion Pipeline Initiative
Sarah Wilson Community-Driven Implementation of Stigma Interventions in African American Faith Communities 2023 Community-led research topic
N. Lance Okeke Evidence2Practice (E2P): Leveraging implementation science to recruit HBCU/MSI students into careers in HIV research, Phase II.  2022 CFEIPI Supplement-CFAR Diversity, Equity, and Inclusion Pipeline Initiative
Sarah Wilson Equity-focused implementation mapping to improve PrEP uptake and maintenance among Latines. 2022 EHE Supplement-Equity-focused approaches to reduce HIV-related health disparities
Amy Corneli EHE: Preparing for implementation of strategies to promote uptake of long-acting injectable PrEP among Black same gender loving men in HBCU communities 2021 EHE Team-initiated Implementation Research
Mehri McKellar Providing A Resource: Telehealth at Needle Exchanges to Reach Underserved People (PARTNER UP) 2021 Increasing the Integration of Substance Abuse Services and HIV Prevention and Care
Charles Muiruri Addressing barriers to achieving cardiometabolic disorders treatment goals for persons living with HIV in the Southeastern United States Award 2021 Disparities in Treatment and Outcomes in People with HIV with multiple comorbidities and co-infections
Susan Reif Increasing the Integration of Substance Abuse Services and HIV Prevention and Care Award 2021 Increasing the Integration of Substance Abuse Services and HIV Prevention and Care
Amy Corneli PrEP-MECK: Increasing PrEP uptake among Same Gender Loving Men in Mecklenburg County, North Carolina 2020 EHE Team-initiated Implementation Research
Amy Corneli & Meredith Clement Getting to [NO]ne in New Orleans: Enhancing PrEP Uptake in Black Women to End the Epidemic 2019 Ending the HIV Epidemic
Amy Corneli PrEP-MECK: Identifying community-driven approaches for increasing PrEP uptake, adherence, and persistence among Black men who have sex with men in Mecklenburg County, North Carolina 2019 Ending the HIV Epidemic
Yvonne Mowery Head and Neck Cancer Treatment in People Living with HIV: Measuring Outcomes And Toxicities to Develop a Standard of Care 2018 NIDCR
Schenita Randolph A Qualitative Study to Examine the Feasibility and Acceptability of a Beauty Salon-Based Intervention to Increase Awareness and Uptake of PrEP among Black Women Living in the United States South 2018 NINR
Mehri McKellar PrEP for PWID: Gathering Evidence for Integrating PrEP into SSPs 2017 NIH/NIAID
Matthew Rubach & John Crump Investigating Febrile Deaths in Tanzania 2017 NIH/NIAID
N. Lance Okeke & John Mitchell Advancing PrEP 2016 NIH/NIAID
David Murdoch Longitudinal assessment of T cell reconstitution in HIV/TB coinfected patients 2011 NIH/NIAID
David Pickup Improved MVA vaccines against HIV 2011 NIH/NIAID

Faculty recruitment (professional network development)
The Developmental Core provides direct financial support to allow recruitment of talented faculty in targeted areas who complement and enhance the CFAR HIV/AIDS research agenda. The Developmental Core may partner with other Departments, Centers, or Institutes in the recruitment or retention of faculty members performing HIV/AIDS research. Please contact the Developmental Core to recommend a faculty recruit that may be suitable for a support from the CFAR Developmental Core.

Mentoring
The Developmental Core provides mentoring resources to ensure effective mentoring is available to support junior faculty members. Mentoring resources include tools to enhance a previously developed mentoring plan (mentor and mentee evaluation forms, mentoring plan templates, etc.) or assistance with developing a mentoring plan or selecting a mentor. Assistance with grant preparation and grant pre-review prior to submission to external funding agencies is also available.
Mentoring Resources

Grant Review process.
CFAR Pilot Grant applications are reviewed by an internal study section using the NIH review and scoring process. The study section review committee is composed of representatives from all Cores and other CFAR membership as expertise is needed. Since 2022 the committee has also included an external reviewer from another CFAR as part of inter-CFAR synergy. The review committee includes ESI as mentored reviewers, providing training in the grant review process for ESI as well as insight into how their own grant applications could be improved. Three reviewers are assigned to each application which is scored according to NIH review criteria, followed by an NIH-style table review. Microgrant proposals are reviewed by the Core and the CFAR Executive Committee, like NIH review of administrative supplements.

Early Career Grant Review Training
The Core staff will provide early career grant review training by inviting senior postdocs and junior faculty to participate in the CFAR Pilot Grant Review process and receive mentoring around the review of a grant application. This training provides insight into the process behind an NIH-style study section review.

Approach for Inclusion of ESI Reviewers and Training
1. ESI reviewers (Asst. Prof, Instructors, senior Postdoctoral Fellows) are selected from previous Pilot awardees or nominated by Duke CFAR members.
2. ESI reviewers go through a formal training session conducted by the Developmental Core explain NIH-style review.
3. ESI reviewers are assigned one or two Pilot grants as ‘Reviewer 3’ and can receive guidance and feedback from a senior reviewer mentor.
4. Following written critiques, all reviewers participate in a table NIH-style review session.
5. ESI reviewers receive feedback on their critiques, participation in the table review and are given the opportunity to also give feedback on the experience.
6. Subsequent follow-up is used as part of the Intra-CFAR Core mentoring and training in grant writing.

 

Developmental Core group email: cfar-dev-core@duke.edu

Leadership:

Keith Reeves

Director, CFAR Developmental Core
R.Keith Reeves, Ph.D.
Professor of Surgery
keith.reeves@duke.edu

Pollara

Associate Director for Basic Research, CFAR Developmental Core
Justin Pollara, Ph.D.
Assistant Professor in Surgery
justin.pollara@duke.edu

Jason Stout

Associate Director for Clinical Research, CFAR Developmental Core
Jason Stout, M.D.
Professor of Medicine
stout002@mc.duke.edu

Reif

Associate Director for Social and Behavioral Research, CFAR Developmental Core
Susan Reif, PhD
Research Associate, Center for Health Policy & Inequalities Research and Duke Global Health Institute
susan.reif@duke.edu

Tonia Poteat

Associate Director, Developmental Core, Duke Center for AIDS Research
Tonia Poteat
Co-Director, Duke Sexual and Gender Minority Wellness Program
Consulting Associate in the School of Nursing
tonia.poteat@duke.edu

Kelly Suñé, Program Coordinator kelly.sune@duke.edu