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Neutralizing Antibody Assays

Monday, June 16, 2014

The CFAR NAb Core provides standardized assessments of the magnitude, breadth, kinetics and duration of vaccine-elicited neutralizing antibody responses in preclinical and clinical trials of candidate HIV and SIV vaccines using validated assays and standardized reference strains in a GCLP-compliant environment. These same assays are used to assess the magnitude and breadth of neutralizing activity of serum samples and monoclonal antibodies from infected individuals. We also offer neutralizing antibody epitope mapping service.

Brief descriptions of our two validated neutralization assays are given included below. Additional information, including detailed non-document controlled assay protocols, macros, educational materials and related links may be found at: