DURHAM, N.C. – Researchers have cleared a major obstacle in the development of an HIV vaccine, proving in animal models that effective, yet short-lasting antibodies can be coaxed into multiplying as a fighting force against the virus.
The finding, led by a team of researchers at the Duke Human Vaccine Institute (DHVI) and Boston Children’s Hospital, publishes online Dec. 5.
“The reason we don’t have a vaccine is because the immune system doesn’t want to make the kind of antibodies that are needed to neutralize the virus,” said co-senior author Barton F. Haynes, M.D., director of the DHVI. “This study is proof of concept that we can engineer the immune system to create an environment where the right antibodies can be made.”
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