PAR-17-471, Detection of HIV for Self-Testing (R61/R33)
Publication date: August 25, 2017
Due dates: December 6, 2017, December 6, 2018, and December 6, 2019 (one receipt date per year)
NIAID and NIMH are encouraging grant applications for bi-phasic developmental, proof-of-concept research focused on innovative strategies to detect HIV within the first two weeks of infection or to monitor viral rebound after stopping or developing resistance to antiretroviral therapy. The goal is to develop simple diagnostic tools that would be feasible for a self-testing platform to allow untrained individuals to detect HIV.
Proposed research projects should establish proof-of-concept for simple qualitative or semi-quantitative diagnostic assays that directly detect HIV (RNA, DNA, and/or protein) or other biomarkers that reliably correlate with viral load or rebound. Such assays would complement existing self-testing tools that detect the host antibody response to HIV. Research objectives may include either the initial development of a novel technology or adaptation of an emerging technology to detect HIV in a self-test platform. Interdisciplinary collaborations that include biomedical, physical, and behavioral sciences are highly encouraged.