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Maternal supplementation of vitamin A deficient hosts with retinyl palmitate to increase passive transfer of HIV vaccine-elicited antibodies to offspring

Maternal supplementation of vitamin A deficient hosts with retinyl palmitate to increase passive transfer of HIV vaccine-elicited antibodies to offspring

Over 19 million pregnant women are vitamin A deficient. Vitamin A deficient, HIV infected, pregnant women have an increased risk of transmitting HIV to their child and may be less responsive to HIV vaccines. Studies will be performed in pregnant rabbits to determine if different forms of Vitamin A supplements, given at the same time as HIV vaccines, increase breast milk anti-HIV antibody responses. The intern would help perform the following analysis: (1) Evaluate the ability of maternal supplementation of vitamin A deficient hosts with retinyl palmitate to increase passive transfer of HIV vaccine-elicited antibodies to offspring; (2) Determine if maternal supplementation of vitamin A deficient hosts with retinyl palmitate combined with maternal vaccination results in increased rabbitpox neutralizing antibody responses in offspring.

The intern wold have the opportunity to perfrom ELISA to measure total and antigen-specific antibody responses in the lab