High-throughput pipeline for cryo-EM data processing
- HIV/- AIDS mentor: Priyamvada Acharya (firstname.lastname@example.org), Director, Division of Structural Biology, Duke Human Vaccine Institute (DHVI)
Cryo-Electron Microscopy (cryo-EM) is a rapidly advancing field; the 2017 Nobel prize in chemistry was awarded to three scientists ‘for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution’. The Division of Structural Biology at the DHVI utilizes cryo-EM to study the entry mechanism of HIV-1 and other viruses, and then applies this knowledge for the development of vaccines and therapeutics. This project will involve optimization of computational pipelines for rapid processing of cryo-EM data collected on the Duke Titan Krios.
- Opportunity to learn cryo-EM.