You are here

Comparison of Antibodies

Comparison of Antibodies

Both influenza and HIV-1 are pathogens with a high degree of diversity and neither can be prevented by long-lasting vaccines. Antibodies to different regions of the main proteins for each virus (hemagglutinin for influenza, envelope for HIV-1) can provide protection in passive challenge models. Antibodies with broad activity against HIV-1 are difficult to elicit, while those for influenza appear to be more readily elicited in humans. A fundamental question is whether antibodies to homologous regions (eg, the stalk of hemagglutinin and the membrane proximal external region of envelope) have similar characteristics. Understanding these characteristics could lead to more rational vaccine designs.